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Xenobiotics can be accumulated in fish through direct uptake from water, dermal exposure, or gill uptake, or via the ingestion of suspended particles or contaminated food (Kleinow et al., 2008

Methyl transferases use SAMe to transfer a methyl group (CH a carbon with three hydrogens attached) onto other molecules

Total RNA from the liver tissue (100 mg) and HepG2 cells were extracted using TRIzol reagent (#15596026, Invitrogen, Waltham, MA, USA) according to a previously described method [20]