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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

That review may include a certificate of analysis, product documentation, lot-level records, batch review, and RUO labeling

CagriSema still shows substantial, clinically meaningful weight loss, and the GLP-1 + amylin combination remains a highly interesting biological strategy

10.1016/j.ecoenv.2025.117964 138 YasudaM.TanakaY.RyuM.TsudaS.NakazawaT