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A phase II study evaluated the efficacy of tepotinib in patients with advanced NSCLC with METex14 alterations ( n = 66) and the tissue-biopsy group ( n = 60) were 48% and 50%, respectively

A reasonable titration schedule might look like this: Week 1: 200mcg once daily Week 2: 300mcg once daily Week 3 onward: 300-500mcg based on response and tolerance Optimizing injection technique Poor injection technique contributes to injection site reactions and potentially to other effects like nausea from anxiety around the process

Leontovy R, Young ND, Korhonen PK, Hall RS, Bulantov J, Jebkov V, et al

Selenium dependent glutathione peroxidase are other GSH-linked enzymes that catalyze the reduction of peroxides using GSH as the reducing agent [7]