The cells that overexpressed the transporters have been found to contain low levels of 6-TGN and other thiopurine metabolites ( thiopurine cellular circulation , whereby thiopurine nucleotides extruded by ABCC4 will be salvaged by an extracellular enzyme NT5E through hydrolysis into nucleosides, before being transported back into the cells by nucleoside transporters ( Finally, several genetic markers and enzymes have been reported to cause thiopurine resistance, but the mechanisms are obscure
Nayan Patel: Again, it's a low concentration, so it's low enough that, keep in mind, your skin is exposed to the environmental toxins the most
Unlike genetic resistance, these phenotypes enable fungal cells to survive high concentrations of antifungals without a measurable increase in minimum inhibitory concentration (MIC), contributing to chronic and relapsing infections (Berman and Krysan, 2020)
The bottom line: autism has many roots