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Filters were promoted as having a variety of materials such as charcoal, cellulose acetate, perforated paper, and polypropylene glycol. The misleading terms low tar, mild, and light would be added to advertising for filtered cigarettes in the 1960s

Cigarette makers have since replaced those words with colors such as gold, silver, blue and orange on such brands, which usually feature different filters and milder-flavored blends

The full list of significantly altered genes is shown in Supplementary Tables 13

This most recent model in the IQOS range was the company's first tobacco-heating device using state-of-the-art induction-heating technology