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Joint aspiration for laboratory analysis may ultimately be required, as it can identify urate crystals, and Gram stain or culture can confirm/exclude the presence of infection

For example, increased Rac1 activity, either through KO/knockdown of Rac1 upstream GAP proteins such as alpha-chimaerin and BCR/ABR, or the expression of constitutively active Rac1 mutants, led to unstable theta-burst stimulation (TBS)-induced LTP that gradually decayed to the baseline response at the CA1 synapse (Oh et al., 2010

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