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Standard GHK-Cu Dosage Ranges in Clinical Practice Most GHK-Cu protocols in research and clinical settings start at 0.51 mg weekly or 23 mg monthly via subcutaneous injection
Simultaneously, some cells undergo cell cycle arrest and become senescent owing to the inhibition of cyclin-dependent kinases mediated by p21 activation through the DDR pathway 11
No adverse effects observed
The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity
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