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(PMID: 15068981) Intravenous vitamin injections: where is the evidence

Leukemic blasts demonstrate: (1) elevated iron uptake via transferrin receptor (TFRC) overexpression [8, 9], (2) heightened mitochondrial reactive oxygen species (ROS) production [10, 11], (3) dysregulated glutathione synthesis pathways [12, 13], and (4) metabolic dependencies on cysteine and glutamine that maintain redox homeostasis [12, 14]

A variety of signaling pathways, such as ERK1/2 [28], JNK1/2 [29], p38MAPK [30], PKC [31], and PI3K [32, 33], and transcription factors, such as c-Jun [29], NF-B [27], JunD [34], and Nrf2 [25], etc., have been found to be involved in the regulation of GCLC and GCLM genes