Key Mechanistic Differences# The mechanistic distinction is significant: Dihexa promotes structural synaptic plasticity through growth factor signaling (building new connections), while PE-22-28 modulates functional neuronal properties through ion channel blockade (changing how existing neurons fire)
Interaction Neuronal cells, myoblast, T cells, B cells, NK cells Ligand/Receptor IGF-I receptor, Insulin receptor isoform A, and IGF-II receptor (M-6-P-R) Bioactivity Human LR3 IGF-1 induces the proliferation of MCF-7 human epithelial cells
How it works: Kisspeptin-10 binds to the KISS1R receptor (also called GPR54) on GnRH-secreting neurons in the hypothalamus
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