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[19] [20] In practice, Lipo-B injections may help boost energy and metabolism in individuals who are trying to lose weight, thereby supporting their weight loss efforts when combined with healthy lifestyle changes

However, one puzzling feature of this initial work is that the binding affinity for Ni II and Co II ions are in the low micromolar range, 224 which is significantly less sensitive than the corresponding Ni II - and Co II -sensing metalloregulatory proteins that have affinities in the (sub)-nanomolar range of bioavailable metal (Figure 8A)

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