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Taken together, the available evidence suggests that smoking influences MS through both early inflammatory and later immune-aging pathways: it may enhance susceptibility and relapse activity through pro-inflammatory, oxidative, and epigenetic mechanisms, while simultaneously accelerating immunosenescence-related processes that favor progression and chronic neurodegeneration

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As president, Reagan implemented sweeping new political and economic initiatives

11 Cardiovascular Disease Smoking impairs the heart and blood vessels, making it more likely for a person who smokes to develop cardiovascular diseases such as coronary artery disease, heart attack, and stroke