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Coformulation vehicle 21 was prepared as described in example 1 except that addition of active pharmaceutical ingredients was abstained from

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Immunohistochemical staining The procedure was previously described ( Malondialdehyde and glutathione assays A lipid peroxidation MDA assay kit (Beyotime, Shanghai, China) was used to determine the relative MDA concentrations in myocardial tissues following the manufacturers protocol