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Whole brain radiotherapy and RRx-001: two partial responses in radioresistant melanoma brain metastases from a phase I/II clinical trial: a TITE-CRM phase I/II clinical trial

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[9] Sermorelin (GRF 129) is even more transient, with a plasma half-life on the order of 1020 minutes in humans, limited by renal ultrafiltration and enzymatic degradation at the N-terminus

This design reduces a major confound: medication effects that can otherwise blur whether biochemical changes precede symptoms or result from treatment