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In a study performed to dissect the role of mGlu2 and mGlu3 receptors in the endogenous control of inflammatory pain, mice lacking mGlu2 receptors showed amplification of pain in the second phase of the formalin test, which reflects the development of nociceptive sensitization in the spinal cord [165]

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It is commonly studied for its interaction with the growth hormone secretagogue receptor (GHSR-1a), making it a frequent subject in metabolic, regenerative, and endocrine research models