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These beneficial effects manifested with altered gene expression, including genes that increased ( Egr, Nos3, Srf, and Kras ) and genes that decreased ( Egr1, Vegfr2, and Plc ), while Akt1 remained unchanged in the inferior caval vein, the right ovarian vein and the left ovarian vein (Vukojevic et al., 2018)

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1 At high concentrations K m ) m max Clinical Implications of Michaelis-Menten Kinetics Drugs that have a therapeutic range that falls on the steep, transitional part of the Michaelis-Menten curve are said to have a narrow therapeutic index and pose significant clinical challenges