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Dihexa's mechanism as a hepatocyte growth factor (HGF) mimetic depends entirely on its hexapeptide structure remaining intact

This process may be associated with the onset and progression of certain diseases, necessitating further experimental validation

Wo I, Tabarkiewicz J (2021) Effect of interleukin-6, -17, -21, -22, and -23 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis

Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation