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Inhibition of NNMT rebalances cellular methyl economy and NAD salvage flux, with downstream effects on adipocyte energetics, lipid handling, and insulin action observed in preclinical systems [13]

Cell 186 , 4365-4385.e27 (2023)

Effect of DSIP In Chronic Pain and Depression The use of DSIP in patients with chronic pain and depression, or both, was another important clinical indication for this neuropeptide