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Look for practitioners who are certified in functional medicine (IFMCP), environmental medicine, or who have specific training in the Shoemaker Protocol

Hormonal fluctuations : Changes related to pregnancy, birth control, or other hormonal shifts can trigger increased pigmentation

While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]

RETRACTED ARTICLE: Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats