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Activated caspase-8 can trigger apoptosis either directly by proteolytically activating the downstream effector caspases, caspases-3, (-6) and -7, however can also proteolytically activate the BH3-only protein BID, thereby increasing effector caspase activation by engaging the intrinsic apoptotic pathway (see above) [10]

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But now the deal is done and the boat will be transported from Florida to Kentucky next month for the Lake Cumberland Poker Run, which is where Ellis will take delivery of his new prize