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Reactive astrocytes, in response to oxidative stress, alter the expression of key enzymes such as nitric oxide synthase (NOS), NADPH oxidase (NOX) enzymes and fatty acid amide hydrolase, which, in turn, enhance the production of oxidative agents 93

doi: 10.1038/gt.2012.81 183 TraisterRSFabreSWangZXiaoXHirschR

Subsequently, we employed the incorporation of maleimide-liposomes, renowned for their capacity to disrupt the ROS delivery system, to ameliorate the drugs water solubility and pharmacokinetics, thereby enhancing its ROS-disruptive efficacy