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That said, if your dog has developed a lung tumor you may notice one or more of the following signs depending on the size and location of the tumor: Coughing Lethargy Rapid breathing Vomiting Weight loss Labored breathing Lameness Hair loss Loss of appetite Reduced exercise tolerance Wheezing Fever Gastrointestinal ulcers Both primary lung cancer and metastatic lung cancer have similar symptoms although coughing is less common with metastatic tumors

Nicotine was the substance most strongly associated with sleep disruption