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Cell apoptosis was quantified via Annexin V-FITC/PI staining followed by flow cytometric analysis, differentiating early and late apoptotic cells

However, the story is nuancedthe failure of the EVOKE trials testing oral Semaglutide in symptomatic Alzheimers Disease does not invalidate the strong epidemiological signal for GLP-1 agonists in dementia prevention, and SS-31s approval establishes important regulatory precedent for mitochondrial-targeted therapeutics