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As little as 1 milligram (mg) of nicotine can cause symptoms in an infant

You just feel sick.[84] A 2011 study on the prevalence of respiratory and allergic symptoms among non-smoking farmworkers in eastern North Carolina found nearly one-quarter reported wheezing at times, with elevated odds of wheezing for individuals working in tobacco production.[85] Public health research among adult workers has also shown that workers exposed to tobacco dust during curing and baling showed significantly lower lung function than unexposed workers.[86] Eye and Mouth Irritation Some child tobacco workers told Human Rights Watch that liquid from wet tobacco plants would splash into their eyes or mouths while they were working in the fields, causing pain, itching, or other irritation

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Japan, the first country where IQOS was launched originally in late 2014 as a city pilot, remains the country with the highest number of heated tobacco product users in the world