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Low-dose protocols (0.250.5mg daily) are derived from studies where systemic copper peptide administration at 24 mcg/kg demonstrated follicle-stimulating activity without elevating serum copper above the normal range (70140 mcg/dL)

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View on PubMed Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Demonstrated AOD9604 intra-articular injection reduced cartilage degradation and inflammatory markers in a collagenase-induced knee osteoarthritis rabbit model, with the combination of AOD9604 and hyaluronic acid showing additive chondroprotective effects (Ann Clin Lab Sci, 2015)