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FBXW7 alleviates harmful processes that lead to DR, such as DNA damage, mitochondrial dysfunction, ROS elimination, and PARP overactivation (125)

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Figure 13 Ganaxolone (3-hydroxy-3-methyl-5-pregnane-20-one), an orally bioavailable synthetic analog of ALLO, is a positive allosteric modulator of GABA A R with promising basic and early-stage clinical outcomes as a potential novel treatment for PTSD (388, 390392)

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