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Clinical onset and course, response to treatment and outcome in 24 patients with the cblE or cblG remethylation defect complemented by genetic and in vitro enzyme study data

Fundamental neuroscience

Neutrophils contribute to RA in various ways: (I) they possess a pool of highly toxic proteases that are released at sites of inflammation (II) activated neutrophils can secrete a variety of pro-inflammatory cytokines and chemokines, causing subsequent inflammation (III) activated neutrophils form neutrophil extracellular traps, which contain externalized citrulline proteins as a source of modified autoantigens for the production of ACPAs [7]

These inhibitors were entered into the LigPrep tool of the Schrodinger 2023.1 suite (Schrodinger, LCC) to generate 3D structures using a pH of 7.4 0.2 (Wessler et al., 2015)