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Research looks at mechanisms such as reducing oxidative stress, modulating growth factors, and impacting extracellular matrix and how all of these connect to gamete quality, implantation, and tissue repair after injury

In the in vitro culture system of lamina propria mononuclear cells (LPMC) or peripheral blood mononuclear cells (PBMC) derived from CD patients, butyrate acts as a specific inhibitor of class I histone deacetylases (HDACI) and exhibits high responsiveness

Meanwhile, IL6 can promote migration and invasion by inducing the expression of matrix metalloproteinases (MMPs) and activating epithelial-mesenchymal transformation 35

Vance et al., 2016