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Wraparound bruises or circumferential wounds or bruising on the wrists, ankles, neck, or at the corners of the mouth are virtually pathognomonic of physical abuse

As such, FDA could create an OTC monograph for e-liquids, for example, which would create a standardized predicate e-liquid that all products would compare against, and require Harmful and Potentially Harmful Constituents (HPHCs) testing, toxicity analysis, and compliance with pharmaceutical GMPs, etc

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Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability