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Clinical trials analysing a class of cancer medication called small-molecule tyrosine kinase inhibitors, which targets a family of proteins that are mutated in many types of cancer, showed that never-smokers, individuals with adenocarcinoma, women and people with east Asian ancestry were more likely to respond well to the drugs than people with a history of smoking 2

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However, the guidelines were released with a recommendation for further research to improve screening uptake and identify biomarkers that could more accurately detect people likely to benefit from screening

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