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Irritability and Anxiety Poor sleep Gross motor problems or problems with coordination Tics Seizures (including absence seizures) If the child has untreated CFD, seizures may start at puberty Problems with vision Developmental delay and/or slowing of typical development Smaller head circumference (but certainly not always) Rett Syndrome maybe in indicator of CFD Depression *Not all these symptoms are seen in kids with CFD What Causes Cerebral Folate Deficiency

b) the widespread use of antibiotics in animal farming, which impairs B12 production by the animal gut microbiota

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However, there is considerable research showing that the bioavailability of peptides and proteins that are taken directly into the gastrointestinal tract is very poor