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Gene expression profiling studies, particularly the Broad Institute Connectivity Map analysis published by Pickart and colleagues, demonstrated that GHK-Cu modulates the expression of approximately 4,000 human genes, representing roughly 6% of the human genome

Similarly, mutations in the ATP13A2 gene associated with PD result in widespread lysosomal impairment, characterized by membrane instability, impaired acidification, reduced processing of lysosomal enzymes, and diminished degradation of substrates and autophagosomes [118]

doi: 10.1089/jwh.2008.1255 298 Prez-TorresIManzano-PechLRubio-RuzMESotoMEGuarner-LansV

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