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Reused or unclear packaging Every B12 session should use sealed, dated, lot-numbered packaging opened in front of you

Simple timing framework Baseline Discuss baseline labs before starting, especially if there is active injury, gut symptoms, infection concern, liver disease, kidney disease, or medication use

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Intrinsic factor is efficient at absorbing a high percentage of a small dose of B12, but it becomes saturated after a meal containing an above-average amount of B12, and about 4 to 6 hours are required before it can efficiently absorb another dose (Institute of Medicine, 1998)