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This pathogenic cascade is central to celiac disease, where gluten is an established environmental trigger rather than a hypothetical contributor ( HT is the most common autoimmune cause of hypothyroidism and results from loss of immune tolerance to thyroid antigens, particularly thyroid peroxidase and thyroglobulin

Differential gene expression analysis was performed using DESeq2 (ref

No published trials document adverse events from combining them, but clinical benefit from the combination is also unproven

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