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Management is focused on early resuscitative therapy with fluids and supportive care

10.1111/boc.202300042 14 ChoY.JeongS.KimH.KangD.LeeJ.KangS

Combined use demonstrates improved outcomes in animal research, including: Faster formation of granulation tissue and wound closure Reduced edema and inflammation Enhanced tendon-to-bone integration and ligament tensile strength Systemic protection of organs such as liver and kidney in ischemia-reperfusion models Systematic reviews of over 35 preclinical studies consistently report positive histological and functional results, with no observed toxicity

Most patients notice improvement in fatigue and general symptoms within days to weeks of starting B12 injections