2.2.4 FSP1 and other emerging regulatory factors Alongside the critical role played by the GPX4 system, the ferroptosis suppressor protein 1 (FSP1)-coenzyme Q10 (CoQ10) pathway independently regulates ferroptosis ( Additionally, recent findings have identified GTP cyclohydrolase-1 (GCH1), dihydroorotate dehydrogenase (DHODH), and several other factors as ferroptosis regulators, further expanding the ferroptosis network and offering new directions for elucidating ferroptosis in OA ( 2.3 Overview of ferroptosis-associated changes in OA tissues Recent studies have established a strong association between ferroptosis and the pathological features of OA, including cartilage degeneration, subchondral bone remodeling, and synovial inflammation
Pan C, Kumar C, Bohl S, Klingmueller U and Mann M 2009 Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions
Antioxidant and anti-inflammatory activity of coffee brew evaluated after simulated gastrointestinal digestion
The current study shows that iron levels in plaque tissue, particularly in macrophages, are significantly elevated and are associated with AS (Thong, Selley, and Watt 1996