Plant Physiol 161:17831794 Rizhsky L, Hallak-Herr E, Van Breusegem F, Rachmilevitch S, Barr JE, Rodermel S, Inz D, Mittler R (2002) Double antisense plants lacking ascorbate peroxidase and catalase are less sensitive to oxidative stress than single antisense plants lacking ascorbate peroxidase or catalase
Vitamin C (especially L-ascorbic acid) works on the surface and upper layers of skin
Enhancing GSH, mainly through NAC, GSH precursors or pro-GSH compound administration, becomes a potential treatment option for SARS-CoV-2 infection and COVID-19 disease by reducing oxidative stress and cytokine expression especially in diabetic patients at risk of more severe disease (Singh et al., 2022)
(B) Aggregated results of 295 human scRNAseq datasets showing expression of genes for canonical melatonin receptors, melatonin synthesis, and the NRF2-Glutathione pathway