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When this barrier is disrupted, RPE cell activation occurs, leading to the proliferation, epithelial-mesenchymal transition (EMT), and secretion of extracellular matrix molecules, thus promoting vitreoretinal disorders, including proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), and proliferative diabetic retinopathy (PDR) [1,2,3]

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The choice between semaglutide and tirzepatide depends on factors beyond B12 formulation: insurance coverage, weight loss goals , side effect tolerance, and whether oral or injectable delivery is preferred