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5.1.2 Coordination between hepatic detoxification and renal excretion The liver, serving as the central node of the gut-liver-kidney axis, plays a critical role in DKD progression through its metabolic dysfunction

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It was found that the combined supplementation of 2 M Lup + 0.75 M Vit A in semen cryopreservation extenders significantly upregulated the transcriptional levels of antioxidant genes such as SOD1 , NRF2 and GPX4 , concurrently, a notable upregulated was also observed with Vit A supplementation alone, and these findings further confirm that the addition of Vit A and Lup enhances antioxidant enzyme levels

It was found that this polymorphism did not increase the risk of melanoma (225)