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Overall, and as our findings also imply, the nature of tobacco effects may crucially depend on the plant material used, its preparation and ingredients added, as well as the context of administration (see also concept of set and setting in psychoactive plant use, Noteworthy is further the healers account of a direct link between intestines and brain involved in the therapeutic mechanism of ingested tobacco, and its beneficial effects on mental parameters related to its action in the gut (expelling of intestinal parasites)

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