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Notably, we previously showed that administering Tempol (a potent ROS scavenger) or genetically deleting Ncf1 (which impairs the respiratory burst) led to bacterial outgrowth in mice 7

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While a 2014 pooled analysis of seven RCTs concluded neither benefits nor harms of the supplementation in patients with heart failure [126], the 1993 and 2020 RCTs supported the supplementations benefit on improved endothelial function, reduced hospitalization, and reduced serious complications in patients with heart failure [127,128]