HIV lipodystrophy patients showed about 15.2% visceral fat reduction at 26 weeks versus placebo, plus favorable lipid and trunk-fat changes
sudden cardiac death due to arrhythmias Treatment: Management for HC ingestion is supportive (no specific antidotes are available) Observe patients in a monitored setting for signs of respiratory distress Cardiac monitor and pulse oximetry are recommended Patients who show signs of impending respiratory failure, despite supplemental oxygen, may require rapid intubation & ventilation Decontamination of the GI tract generally is not recommended because of the risk of aspiration and the low GI toxicity of most HCs Indicated medications include dextrose, thiamine, and naloxone for altered mental status and albuterol for bronchospasm Notes: The American Association of Poison Control Centers lists HCs as the 12th most common poison exposure In 1997, 3% of cases reported to US poison control centers involved HC exposure
Both familial (fALS, 510% of cases) and sporadic (sALS) forms show similar clinical and pathological features, with overlapping cognitive and behavioral changes, particularly frontotemporal-like symptoms, as well as progressive bulbar and limb motor dysfunction
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