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Epithalon has been extensively evaluated in aging-prone and cancer-prone rodent models, where it has been shown to reduce spontaneous tumor formation, suppress oncogene expression (notably HER-2/neu), and increase median and maximal lifespan 1,2

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This finding is particularly relevant for rotator cuff injuries, where the supraspinatus tendon often cannot bridge large gaps without assistance

For example, TB-500 was found to accelerate dormant tumor growth and disrupt the immune response in animal experiments