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Research also indicates that the gtp cyclohydrolase 1/Tetrahydrobiopterin/dihydrofolate reductase (GCH1/BH4/DHFR) pathway, particularly DHFR, suppresses ferroptosis by promoting BH4 synthesis

Uniprot Knowledgebase (UniProtKB) protein descriptions and gene products were imported into DAVID and FunRich for statistical analyses and GO term annotation based on integrated biological, molecular, and cellular pathways of the differentially expressed proteins

Cuadrado et al., 2020) and pharmacological activation of Nrf2 might also limit NF-B-mediated pulmonary inflammation caused by SARS-CoV-2 infection (Cuadrado et al., 2019, 2020

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