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doi: 10.1038/s41440-019-0248-0 126

Synthetic cannabimimetics (e.g., Spice, JW) also pose a great risk to users and athletes

Observed outcomes include specific cellular and molecular endpoints such as: Enhanced fibroblast migration capacity Increased collagen and elastin deposition Modulation of pro-inflammatory and antioxidant mediators Altered transcriptional profiles related to tissue homeostasis, repair signaling, and stress response All reported observations derive exclusively from preclinical laboratory and animal studies and remain model-specific

When administered subcutaneously, it's absorbed into the bloodstream and distributed system-wide