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naturally small molecular reducing agents will never be as specific as the substrate-specific enzymes of the well-controlled antioxidant machinery of the cell, however with a finely tuned and designed thiolate basicity the redox potential and therefore the selectivity of the antioxidant thiol can be confined to a narrower range

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Notably, PSR-1 undergoes phase-separated condensation, which correlates its function in axonal fusion and can be influenced by oxidative states

2017 Feb 28;18(3):523