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The presence of an expanded polyQ tract in proteins leads to a self-association that competes with polyQ-mediated interaction with beclin-1 and impairs autophagy in vitro (as observed for ATXN3) and in vivo (as observed for huntingtin), at least in conditions of starvation [85]

Until results from this dedicated study are available, its unlikely that cagrilintide will move forward for approval on its own just yet

To fully realize the potential of magnetothermal neuromodulation, future research should focus more deeply on the fundamental biophysical interactions between MFs and biological tissues, particularly the effects of MFs on ion channels and cellular pathways

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