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Description

These linkers include the GFLG peptide which is cleaved by cathepsin B 75 , the PLGLAG peptide which is cleaved by matrix metalloprotease (MMP)-2/9 76 , and the oxime-hydrazone bond which is hydrolyzed in an acidic pH 77

There are no standardized guidelines

Initially EpRE was called the antioxidant response element (ARE) because the first compound, shown to activate ARE was a so-called antioxidant that was subsequently shown to generate H 2 O 2 through redox cycling (Pinkus et al., 1996)