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Indeed, global GSH depletion in mice has been shown to cause rapid weight loss and death within 2 weeks, whereas liver-specific GSH depletion does not result in such systemic toxicity, despite the liver being the primary site of GSH synthesis (12)

We begin by briefly introducing the pathophysiological mechanisms behind various liver diseases, focusing on liver fibrosis, NAFLD, and HCC, as well as the nanomedicines developed to address these issues