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For hydrophilic drugs entrapped in the aqueous core, preventing leakage during separation is paramount

This is the dual GIP/GLP-1 mechanism working at full capacity, slowing gastric emptying, enhancing satiety signaling, and modulating reward pathways related to food

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Di Fulvio et al., 2020) and importantly, some Cl transporters help maintain the intracellular Cl concentration ([Cl ] i ) above its predicted thermodynamic equilibrium, facilitating the movement of Cl out of the cell and through Cl channels in an electrogenic manner