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Modulation of nitric oxide, a smart regulator, not a pump NO (nitric oxide) is an important molecular signal in the body, vasodilation, blood pressure regulation, healing

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Interestingly, we also found a partial involvement of opioid receptors at the central level during the initial neurogenic pain evoked by formalin and the neuropathic pain caused by nerve constriction, although no evidence to date has demonstrated the binding capacity of cortistatin to opioid-receptors